TOXICOLOGY & RISK ASSESSMENT OF CHEMICALS
General Toxicology and In Silico Toxicology
Flashtox integrates traditional and innovative approaches for general toxicology, using in silico methodologies to predict toxicity and develop integrated testing strategies. Trough QSAR models and read-across approaches, we assess the toxicological profiles of chemicals, examining impurities and extractables. Our ability to identify dose descriptors and derive health-based guidance values provides our clients with a solid foundation for product safety management in the following regulatory areas: REACH, CLP, Biocides, Cosmetics, Detergents, Agrochemicals, Pharmaceuticals and POPs. The main activities are as follows:
Flashtox integrates traditional and innovative approaches for general toxicology, using in silico methodologies to predict toxicity and develop integrated testing strategies. Trough QSAR models and read-across approaches, we assess the toxicological profiles of chemicals, examining impurities and extractables. Our ability to identify dose descriptors and derive health-based guidance values provides our clients with a solid foundation for product safety management in the following regulatory areas: REACH, CLP, Biocides, Cosmetics, Detergents, Agrochemicals, Pharmaceuticals and POPs. The main activities are as follows:
General Toxicology and In Silico Toxicology
- Toxicity predictions and integrated testing strategies using non-animal methodologies
- Read-across approach for regulatory submissions
- QSAR-based toxicological hazard profiling
- Impurities, extractables & leachables toxicity assessment
- Dose descriptors/PODs (NOAEL, BMD, LOAEL, etc) identification
- Health-based guidance values (HBGV) (TDI, ADI, BNEL, DMEL, etc) identification and derivation
- Study-design (in silico/in vitro/in vivo) development and implementation
- Study Monitoring
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