TOXICOLOGY & RISK ASSESSMENT OF CHEMICALS
Advanced
Toxicology
In the sphere of advanced toxicology, Flashtox focuses on the assessment of chemical activities such as endocrine disruptors and other specific aspects such as cardiotoxicity, neurotoxicity, and immunotoxicity. We also utilize toxicodynamic and toxicokinetic models as well as ADME models to evaluate the level of bioavailability of ingredients/impurities or components, which are also useful for identifying the mode of action (MoA) and the Adverse Outcome Pathway (AOP). These cutting-edge approaches allow for thorough evaluation and precise management of risks associated with products in the following regulatory areas: REACH, CLP, Biocides, Cosmetics, Detergents, Agrochemicals, Pharmaceuticals and POPs. The main activities are as follows:
In the sphere of advanced toxicology, Flashtox focuses on the assessment of chemical activities such as endocrine disruptors and other specific aspects such as cardiotoxicity, neurotoxicity, and immunotoxicity. We also utilize toxicodynamic and toxicokinetic models as well as ADME models to evaluate the level of bioavailability of ingredients/impurities or components, which are also useful for identifying the mode of action (MoA) and the Adverse Outcome Pathway (AOP). These cutting-edge approaches allow for thorough evaluation and precise management of risks associated with products in the following regulatory areas: REACH, CLP, Biocides, Cosmetics, Detergents, Agrochemicals, Pharmaceuticals and POPs. The main activities are as follows:
Advanced Toxicology
- Endocrine Disruptors Chemicals activity predictions
- Cardiotoxicity assessment
- Neurotoxicity assessment
- Immunotoxicity assessment
- Allergenicity assessment
- Toxicodynamic and Toxicokinetic modelling
- Adsorption, Distribution, Metabolism and Excretion (ADME) and Systemic bioavailability prediction
- MoA (Mode of Action)/ AOP (Adverse Outcome Pathway) development/identification
- NAMs (New Assessment Methodologies) and NGRA (Next Generation Risk Assessment)-based testing plan
- Organ-on-chip (OOC) models
- 2D and 3D cell-culture methods
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